diff --git a/_multibuild b/_multibuild
new file mode 100644
index 0000000..86b0022
--- /dev/null
+++ b/_multibuild
@@ -0,0 +1,3 @@
+<multibuild>
+  <flavor>python</flavor>
+</multibuild>
diff --git a/libxml2.changes b/libxml2.changes
index 6883a33..70519fa 100644
--- a/libxml2.changes
+++ b/libxml2.changes
@@ -1,3 +1,10 @@
+-------------------------------------------------------------------
+Fri Mar 18 09:46:03 UTC 2022 - Dominique Leuenberger <dimstar@opensuse.org>
+
+- Build python bindings in a 2nd run, using multibuild: otherwise,
+  libxml2 requires pkgconfig(libxml-2.0) to build, causing issues
+  to bootstrap.
+
 -------------------------------------------------------------------
 Tue Mar  8 06:32:13 UTC 2022 - Luciano Santos <luc14n0@opensuse.org>
 
diff --git a/libxml2.spec b/libxml2.spec
index 940c07d..dd3c316 100644
--- a/libxml2.spec
+++ b/libxml2.spec
@@ -1,5 +1,5 @@
 #
-# spec file for package libxml2
+# spec file
 #
 # Copyright (c) 2022 SUSE LLC
 #
@@ -18,14 +18,19 @@
 
 %define base_name  libxml2
 %define libname    libxml2-2
+%define flavor @BUILD_FLAVOR@%nil
+%if "%{flavor}" == "python"
+%define dash -
+%define buildpython 1
+%endif
 
-Name:           libxml2
+Name:           libxml2%{?dash}%{flavor}
 Version:        2.9.13
 Release:        0
 License:        MIT
 Summary:        A Library to Manipulate XML Files
 URL:            https://gitlab.gnome.org/GNOME/libxml2
-Source0:        https://download.gnome.org/sources/%{name}/2.9/%{name}-%{version}.tar.xz
+Source0:        https://download.gnome.org/sources/%{name}/2.9/libxml2-%{version}.tar.xz
 Source1:        baselibs.conf
 #
 ### -- Upstream patches range from 0 to 999 -- ###
@@ -46,18 +51,20 @@ Patch1:         libxml2-python3-string-null-check.patch
 # PATCH-FIX-SUSE bsc#1135123 Added a new configurable variable XPATH_DEFAULT_MAX_NODESET_LENGTH to avoid nodeset limit
 Patch2000:      libxml2-make-XPATH_MAX_NODESET_LENGTH-configurable.patch
 #
-BuildRequires:  %{python_module devel}
-BuildRequires:  %{python_module xml}
 BuildRequires:  fdupes
 BuildRequires:  pkgconfig
-BuildRequires:  python-rpm-macros
 BuildRequires:  readline-devel
 BuildRequires:  pkgconfig(liblzma)
-BuildRequires:  pkgconfig(libxml-2.0)
 BuildRequires:  pkgconfig(zlib)
+%if 0%{?buildpython}
+BuildRequires:  %{python_module devel}
+BuildRequires:  %{python_module xml}
+BuildRequires:  python-rpm-macros
+BuildRequires:  pkgconfig(libxml-2.0)
 # TW: generate subpackages for every python3 flavor
 %define python_subpackage_only 1
 %python_subpackages
+%endif
 
 %description
 The XML C library was initially developed for the GNOME project. It is
@@ -122,7 +129,7 @@ The XML C library was initially developed for the GNOME project. It is
 now used by many programs to load and save extensible data structures
 or manipulate any kind of XML files.
 
-%package -n python-%{name}
+%package -n python-libxml2
 Summary:        Python  Bindings for %{name}
 Requires:       %{libname} = %{version}
 Requires:       python-extras
@@ -133,7 +140,7 @@ Provides:       python-libxml2-python = %{version}-%{release}
 Obsoletes:      %{base_name}-python < 2.9.13
 Obsoletes:      python-libxml2-python < 2.9.13
 
-%description -n python-%{name}
+%description -n python-libxml2
 This package contains a module that permits
 applications written in the Python programming language to use the
 interface supplied by the libxml2 library to manipulate XML files.
@@ -147,6 +154,7 @@ either at parse time or later once the document has been modified.
 %autosetup -p1 -n libxml2-%{version}
 
 %build
+%if ! 0%{?buildpython}
 # TODO -- Document why are we using the -fno-strict-aliasing extra flag.
 export CFLAGS="%{optflags} -fno-strict-aliasing"
 %configure \
@@ -165,11 +173,14 @@ export CFLAGS="%{optflags} -fno-strict-aliasing"
     --with-http
 
 %make_build BASE_DIR="%{_docdir}" DOC_MODULE="%{base_name}"
+%else
 pushd python
 %python_build
 popd
+%endif
 
 %install
+%if ! 0%{?buildpython}
 %make_install BASE_DIR="%{_docdir}" DOC_MODULE="%{base_name}"
 find %{buildroot} -type f -name "*.la" -delete -print
 mkdir -p "%{buildroot}/%{_docdir}/%{base_name}"
@@ -178,13 +189,15 @@ ln -s libxml2/libxml %{buildroot}%{_includedir}/libxml
 # Remove duplicated file Copyright as not found by fdupes
 rm -fr %{buildroot}%{_docdir}/%{base_name}/Copyright
 %fdupes %{buildroot}%{_datadir}
-
+%else
 pushd python
 %python_install
 popd
 chmod a-x python/tests/*.py
 %python_expand %fdupes %{buildroot}%{$python_sitearch}
+%endif
 
+%if ! 0%{?buildpython}
 %check
 # qemu-arm can't keep up atm, disabling check for arm
 %ifnarch %{arm}
@@ -227,12 +240,15 @@ chmod a-x python/tests/*.py
 %dir %{_datadir}/gtk-doc
 %dir %{_datadir}/gtk-doc/html
 
-%files %{python_files %{name}}
+%else
+
+%files %{python_files libxml2}
 %doc python/TODO
 %doc python/libxml2class.txt
 %doc doc/*.py
 %doc doc/python.html
 %pycache_only %{python_sitearch}/__pycache__/*libxml2*
 %{python_sitearch}/*libxml2*
+%endif
 
 %changelog