diff --git a/.gitlab-ci.yml b/.gitlab-ci.yml
index 478739b85..a77836e5b 100644
--- a/.gitlab-ci.yml
+++ b/.gitlab-ci.yml
@@ -458,8 +458,7 @@ macos:
             --werror
             _build
     - ninja -C _build
-    # FIXME: Multiple unit tests currently fails
-    - .gitlab-ci/run-tests.sh || true
+    - .gitlab-ci/run-tests.sh
   artifacts:
     reports:
       junit: "_build/${CI_JOB_NAME}-report.xml"
diff --git a/gio/tests/meson.build b/gio/tests/meson.build
index eab7999e6..e8d10a0f1 100644
--- a/gio/tests/meson.build
+++ b/gio/tests/meson.build
@@ -42,14 +42,20 @@ giotypefuncs_inc = custom_target(
 
 #  Test programs buildable on all platforms
 gio_tests = {
-  'appmonitor' : {},
+  'appmonitor' : {
+    # FIXME: https://gitlab.gnome.org/GNOME/glib/-/issues/1392
+    'should_fail' : host_system == 'darwin',
+  },
   'async-close-output-stream' : {},
   'async-splice-output-stream' : {},
   'buffered-input-stream' : {},
   'buffered-output-stream' : {},
   'cancellable' : {},
   'contexts' : {},
-  'contenttype' : {},
+  'contenttype' : {
+    # FIXME: https://gitlab.gnome.org/GNOME/glib/-/issues/1392 / https://gitlab.gnome.org/GNOME/glib/-/issues/1251
+    'should_fail' : host_system == 'darwin',
+  },
   'converter-stream' : {},
   'credentials' : {},
   'cxx' : {
@@ -57,14 +63,21 @@ gio_tests = {
   },
   'data-input-stream' : {},
   'data-output-stream' : {},
-  'debugcontroller' : {},
-  'defaultvalue' : {'extra_sources' : [giotypefuncs_inc]},
   'fileattributematcher' : {},
   'filter-streams' : {},
-  'giomodule' : {},
-  'gsubprocess' : {},
+  'giomodule' : {
+    # FIXME: https://gitlab.gnome.org/GNOME/glib/-/issues/1392
+    'should_fail' : host_system == 'darwin',
+  },
+  'gsubprocess' : {
+    # FIXME: https://gitlab.gnome.org/GNOME/glib/-/issues/1392
+    'should_fail' : host_system == 'darwin',
+  },
   'g-file' : {},
-  'g-file-info' : {},
+  'g-file-info' : {
+    # FIXME: https://gitlab.gnome.org/GNOME/glib/-/issues/1392
+    'should_fail' : host_system == 'darwin',
+  },
   'g-icon' : {},
   'gdbus-addresses' : {},
   'gdbus-message' : {},
@@ -74,7 +87,11 @@ gio_tests = {
   'memory-monitor' : {},
   'memory-output-stream' : {},
   'mount-operation' : {},
-  'network-address' : {'extra_sources': ['mock-resolver.c']},
+  'network-address' : {
+    'extra_sources': ['mock-resolver.c'],
+    # FIXME: https://gitlab.gnome.org/GNOME/glib/-/issues/1392
+    'should_fail' : host_system == 'darwin',
+  },
   'network-monitor' : {},
   'network-monitor-race' : {},
   'permission' : {},
@@ -85,7 +102,10 @@ gio_tests = {
   'simple-async-result' : {},
   'simple-proxy' : {},
   'sleepy-stream' : {},
-  'socket' : {},
+  'socket' : {
+    # FIXME: https://gitlab.gnome.org/GNOME/glib/-/issues/1392
+    'should_fail' : host_system == 'darwin',
+  },
   'socket-listener' : {},
   'socket-service' : {},
   'srvtarget' : {},
@@ -99,7 +119,10 @@ gio_tests = {
   'tls-interaction' : {'extra_sources' : ['gtesttlsbackend.c']},
   'tls-database' : {'extra_sources' : ['gtesttlsbackend.c']},
   'tls-bindings' : {'extra_sources' : ['gtesttlsbackend.c']},
-  'gdbus-address-get-session' : {},
+  'gdbus-address-get-session' : {
+    # FIXME: https://gitlab.gnome.org/GNOME/glib/-/issues/1392
+    'should_fail' : host_system == 'darwin',
+  },
   'win32-appinfo' : {},
 }
 
@@ -158,7 +181,9 @@ if host_machine.system() != 'windows'
     'file' : {},
     'gdbus-peer' : {
       'dependencies' : [libgdbus_example_objectmanager_dep],
-      'install_rpath' : installed_tests_execdir
+      'install_rpath' : installed_tests_execdir,
+      # FIXME: https://gitlab.gnome.org/GNOME/glib/-/issues/1392
+      'should_fail' : host_system == 'darwin',
     },
     'gdbus-peer-object-manager' : {},
     'live-g-file' : {},
@@ -297,6 +322,8 @@ if host_machine.system() != 'windows'
         'extra_sources' : extra_sources,
         'suite' : ['slow'],
       },
+      'debugcontroller' : {},
+      'defaultvalue' : {'extra_sources' : [giotypefuncs_inc]},
       'gdbus-auth' : {'extra_sources' : extra_sources},
       'gdbus-bz627724' : {'extra_sources' : extra_sources},
       'gdbus-close-pending' : {'extra_sources' : extra_sources},
@@ -779,6 +806,8 @@ if not meson.is_cross_build() or meson.has_exe_wrapper()
   gio_tests += {
     'resources' : {
       'extra_sources' : resources_extra_sources,
+      # FIXME: https://gitlab.gnome.org/GNOME/glib/-/issues/1392
+      'should_fail' : host_system == 'darwin',
     },
   }
 endif
@@ -832,6 +861,7 @@ foreach test_name, extra_args : gio_tests
     suite : suite,
     is_parallel : extra_args.get('is_parallel', true),
     depends : extra_args.get('depends', []),
+    should_fail : extra_args.get('should_fail', false),
   )
 endforeach
 
diff --git a/glib/tests/meson.build b/glib/tests/meson.build
index 9150f3f44..11563bcfe 100644
--- a/glib/tests/meson.build
+++ b/glib/tests/meson.build
@@ -19,9 +19,15 @@ glib_tests = {
     'source' : ['cxx.cpp'],
   },
   'dataset' : {},
-  'date' : {},
+  'date' : {
+    # FIXME: https://gitlab.gnome.org/GNOME/glib/-/issues/1392
+    'should_fail' : host_system == 'darwin',
+  },
   'dir' : {},
-  'environment' : {},
+  'environment' : {
+    # FIXME: https://gitlab.gnome.org/GNOME/glib/-/issues/1392
+    'should_fail' : host_system == 'darwin',
+  },
   'error' : {},
   'fileutils' : {},
   'gdatetime' : {
@@ -242,7 +248,12 @@ foreach test_name, extra_args : glib_tests
 
   suite = ['glib'] + extra_args.get('suite', [])
   timeout = suite.contains('slow') ? test_timeout_slow : test_timeout
-  test(test_name, exe, env : test_env, timeout : timeout, suite : suite)
+  test(test_name, exe,
+    env : test_env,
+    timeout : timeout,
+    suite : suite,
+    should_fail : extra_args.get('should_fail', false),
+  )
 endforeach
 
 executable('spawn-path-search-helper', 'spawn-path-search-helper.c',