diff --git a/.gitlab-ci.yml b/.gitlab-ci.yml
index 7e1b829cd..9de4be100 100644
--- a/.gitlab-ci.yml
+++ b/.gitlab-ci.yml
@@ -14,6 +14,7 @@ variables:
   FEDORA_IMAGE: "registry.gitlab.gnome.org/gnome/glib/fedora:v22"
   COVERITY_IMAGE: "registry.gitlab.gnome.org/gnome/glib/coverity:v7"
   DEBIAN_IMAGE: "registry.gitlab.gnome.org/gnome/glib/debian-stable:v16"
+  ALPINE_IMAGE: "registry.gitlab.gnome.org/gnome/glib/alpine-stable:v0"
   MINGW_IMAGE: "registry.gitlab.gnome.org/gnome/glib/mingw:v12"
   MESON_TEST_TIMEOUT_MULTIPLIER: 4
   G_MESSAGES_DEBUG: all
@@ -210,6 +211,37 @@ hurd-i386:
       - "_build/glib/glibconfig.h"
       - "_build/meson-logs"
 
+muslc-alpine-stable-x86_64:
+  extends:
+    - .build-linux
+    - .only-schedules
+  image: $ALPINE_IMAGE
+  stage: build
+  needs: []
+  script:
+    - meson setup ${MESON_COMMON_OPTIONS}
+            --werror
+            --default-library=both
+            --prefix=$HOME/glib-installed
+            --localstatedir=/var
+            --libdir=lib
+            -Dsystemtap=true
+            _build
+    - meson compile -C _build
+    - .gitlab-ci/run-tests.sh
+  artifacts:
+    reports:
+      junit:
+        - _build/meson-logs/testlog.junit.xml
+        - _build/meson-logs/testlog-*.junit.xml
+    name: "glib-${CI_JOB_NAME}-${CI_COMMIT_REF_NAME}"
+    when: always
+    expire_in: 1 week
+    paths:
+      - "_build/config.h"
+      - "_build/glib/glibconfig.h"
+      - "_build/meson-logs"
+
 installed-tests:
   extends:
     - .build-linux
diff --git a/.gitlab-ci/alpine.Dockerfile b/.gitlab-ci/alpine.Dockerfile
new file mode 100644
index 000000000..be9ecfa70
--- /dev/null
+++ b/.gitlab-ci/alpine.Dockerfile
@@ -0,0 +1,35 @@
+FROM alpine:latest
+
+RUN apk add --no-cache \
+    bash \
+    build-base \
+    bzip2-dev \
+    dbus \
+    desktop-file-utils \
+    docbook-xml \
+    docbook-xsl \
+    gettext-dev \
+    git \
+    libffi-dev \
+    libxml2-utils \
+    libxslt \
+    meson \
+    musl-locales \
+    python3 \
+    pcre2-dev \
+    shared-mime-info \
+    tzdata \
+    util-linux-dev \
+    zlib-dev
+
+ENV LANG=C.UTF-8 LANGUAGE=C.UTF-8 LC_ALL=C.UTF-8 MUSL_LOCPATH=/usr/share/i18n/locales/musl
+
+ARG HOST_USER_ID=5555
+ENV HOST_USER_ID ${HOST_USER_ID}
+RUN adduser -D -u $HOST_USER_ID -s /bin/bash user
+
+USER user
+WORKDIR /home/user
+
+COPY cache-subprojects.sh .
+RUN ./cache-subprojects.sh
diff --git a/gio/tests/meson.build b/gio/tests/meson.build
index 187a60343..fd4c46fc6 100644
--- a/gio/tests/meson.build
+++ b/gio/tests/meson.build
@@ -64,7 +64,12 @@ gio_tests = {
     # FIXME: https://gitlab.gnome.org/GNOME/glib/-/issues/1392 / https://gitlab.gnome.org/GNOME/glib/-/issues/1251
     'can_fail' : host_system == 'darwin',
   },
-  'converter-stream' : {},
+  'converter-stream' : {
+    # musl: charset tests fail due to missing collation support in musl libc
+    # From https://wiki.musl-libc.org/roadmap#Open_future_goals
+    # "LC_COLLATE support for collation orders other than simple codepoint order"
+    'can_fail' : linux_libc == 'musl',
+  },
   'credentials' : {},
   'data-input-stream' : {},
   'data-output-stream' : {},
@@ -993,6 +998,8 @@ if not meson.is_cross_build()
     'resources' : {
       'extra_sources' : resources_extra_sources,
       'depends' : resource_plugin,
+      # FIXME: musl: https://gitlab.gnome.org/GNOME/glib/-/issues/3160
+      'can_fail' : linux_libc == 'musl',
     },
   }
 endif
diff --git a/glib/tests/meson.build b/glib/tests/meson.build
index d401e759b..60eb31bff 100644
--- a/glib/tests/meson.build
+++ b/glib/tests/meson.build
@@ -12,14 +12,26 @@ glib_tests = {
   'cache' : {},
   'charset' : {},
   'checksum' : {},
-  'collate' : {},
+  'collate' : {
+    # musl: collate fail due to missing collation support in musl libc
+    # From https://wiki.musl-libc.org/roadmap#Open_future_goals
+    # "LC_COLLATE support for collation orders other than simple codepoint order"
+    'can_fail' : linux_libc == 'musl',
+  },
   'completion' : {},
   'cond' : {},
-  'convert' : {},
+  'convert' : {
+    # fails /conversion/illegal-sequence
+    # Possibly a bug or some POSIX incompatibility, not sure if here or in musl
+    'can_fail' : linux_libc == 'musl',
+  },
   'dataset' : {},
   'date' : {
-    # FIXME: https://gitlab.gnome.org/GNOME/glib/-/issues/1392
-    'can_fail' : host_system == 'darwin',
+    # FIXME: darwin: https://gitlab.gnome.org/GNOME/glib/-/issues/1392
+    # musl: /date/month_substring should be skipped but it's not. The fix should
+    # be on musl side: https://www.openwall.com/lists/musl/2023/08/10/3
+    # FIXME: musl: /date/strftime: https://gitlab.gnome.org/GNOME/glib/-/issues/3171
+    'can_fail' : host_system == 'darwin' or linux_libc == 'musl',
   },
   'dir' : {},
   'environment' : {
@@ -30,7 +42,10 @@ glib_tests = {
   'fileutils' : {},
   'gdatetime' : {
     'suite' : ['slow'],
-    'can_fail' : host_system == 'windows',
+    # musl: GDateTime/format_mixed/non_utf8_time_non_utf8_messages should be
+    # skipped but it's not. The fix should be on musl side:
+    # https://www.openwall.com/lists/musl/2023/08/10/3
+    'can_fail' : host_system == 'windows' or linux_libc == 'musl',
   },
   'guuid' : {},
   'gvariant' : {
@@ -70,7 +85,11 @@ glib_tests = {
   'node' : {},
   'once' : {},
   'onceinit' : {},
-  'option-context' : {},
+  'option-context' : {
+    # musl: /option/arg/repetition/locale should be skipped but it's not. The
+    # fix should be on musl side: https://www.openwall.com/lists/musl/2023/08/10/3
+    'can_fail' : linux_libc == 'musl',
+  },
   'option-argv0' : {},
   'overflow' : {},
   'overflow-fallback' : {
@@ -94,6 +113,8 @@ glib_tests = {
   'regex' : {
     'dependencies' : [pcre2],
     'c_args' : use_pcre2_static_flag ? ['-DPCRE2_STATIC'] : [],
+    # FIXME: musl: https://gitlab.gnome.org/GNOME/glib/-/issues/3159
+    'can_fail' : linux_libc == 'musl',
   },
   'relation' : {},
   'rwlock' : {},
diff --git a/meson.build b/meson.build
index 901ae6dfe..2b6f394c7 100644
--- a/meson.build
+++ b/meson.build
@@ -65,6 +65,17 @@ if host_system == 'darwin'
   endif
 endif
 
+linux_libc = ''
+if host_system == 'linux'
+  musl_test_code = '''#include <stdlib.h>
+  #if defined __GLIBC__ || defined __UCLIBC__
+  #error "Not in glibc or uclibc"
+  #endif'''
+  if cc.compiles(musl_test_code, name : 'building for musl libc')
+    linux_libc = 'musl'
+  endif
+endif
+
 glib_version = meson.project_version()
 glib_api_version = '2.0'
 version_arr = glib_version.split('.')
@@ -2552,6 +2563,12 @@ if build_machine.system() != host_system
   }, section: 'Build environment')
 endif
 
+if linux_libc != ''
+  summary({
+    'linux_libc' : linux_libc
+  }, section: 'Build environment')
+endif
+
 summary({
   'prefix' : glib_prefix,
   'bindir' : glib_bindir,