diff --git a/.gitlab-ci.yml b/.gitlab-ci.yml
index 3b6f44ea6..3846535e4 100644
--- a/.gitlab-ci.yml
+++ b/.gitlab-ci.yml
@@ -228,9 +228,6 @@ valgrind:
     - bash -x ./.gitlab-ci/run-tests.sh
                  --setup valgrind
                  --no-suite slow
-  # FIXME: Remove this when we have zero valgrind leaks.
-  # https://gitlab.gnome.org/GNOME/glib/issues/333
-  allow_failure: true
   artifacts:
     reports:
       junit: "_build/meson-logs/testlog-valgrind.junit.xml"
diff --git a/tools/glib.supp b/tools/glib.supp
index b06efec0d..0609db44e 100644
--- a/tools/glib.supp
+++ b/tools/glib.supp
@@ -904,6 +904,126 @@
 	fun:desktop_file_dir_unindexed_setup_search
 }
 
+#gutils.c caches system and user dirs and may need to replace them during tests.
+{
+	g_build_user_data_dir
+	Memcheck:Leak
+	match-leak-kinds:definite
+	fun:malloc
+	...
+	fun:g_build_user_data_dir
+}
+
+#gutils.c caches system and user dirs and may need to replace them during tests.
+{
+	g_build_filename
+	Memcheck:Leak
+	match-leak-kinds:definite
+	fun:malloc
+	...
+	fun:g_build_filename
+}
+
+#gutils.c caches system and user dirs and may need to replace them during tests.
+{
+	g_build_home_dir
+	Memcheck:Leak
+	match-leak-kinds:definite
+	fun:malloc
+	...
+	fun:g_build_home_dir
+}
+
+#gutils.c caches system and user dirs and may need to replace them during tests.
+{
+	g_build_path
+	Memcheck:Leak
+	match-leak-kinds:definite
+	fun:malloc
+	...
+	fun:g_build_path
+}
+
+#gutils.c caches system and user dirs and may need to replace them during tests.
+{
+	g_build_system_config_dirs
+	Memcheck:Leak
+	match-leak-kinds:definite
+	fun:realloc
+	...
+	fun:g_build_system_config_dirs
+}
+
+#gutils.c caches system and user dirs and may need to replace them during tests.
+{
+	g_build_system_data_dir
+	Memcheck:Leak
+	match-leak-kinds:definite
+	fun:malloc
+	...
+	fun:g_build_system_data_dir
+}
+
+#gutils.c caches system and user dirs and may need to replace them during tests.
+{
+	g_build_system_data_dirs
+	Memcheck:Leak
+	match-leak-kinds:definite
+	fun:realloc
+	...
+	fun:g_build_system_data_dirs
+}
+
+#gutils.c caches system and user dirs and may need to replace them during tests.
+{
+	g_build_user_cache_dir
+	Memcheck:Leak
+	match-leak-kinds:definite
+	fun:malloc
+	...
+	fun:g_build_user_cache_dir
+}
+
+#gutils.c caches system and user dirs and may need to replace them during tests.
+{
+	g_build_user_config_dir
+	Memcheck:Leak
+	match-leak-kinds:definite
+	fun:malloc
+	...
+	fun:g_build_user_config_dir
+}
+
+#gutils.c caches system and user dirs and may need to replace them during tests.
+{
+	g_build_user_data_dir
+	Memcheck:Leak
+	match-leak-kinds:definite
+	fun:malloc
+	...
+	fun:g_build_user_data_dir
+}
+
+#gutils.c caches system and user dirs and may need to replace them during tests.
+{
+	g_build_user_runtime_dir
+	Memcheck:Leak
+	match-leak-kinds:definite
+	fun:malloc
+	...
+	fun:g_build_user_runtime_dir
+}
+
+#gutils.c caches system and user dirs and may need to replace them during tests.
+{
+	g_build_user_state_dir
+	Memcheck:Leak
+	match-leak-kinds:definite
+	fun:malloc
+	...
+	fun:g_build_user_state_dir
+}
+
 # g_io_extension_point_register() caches a one-time allocation global table of @extension_points.
 {
 	g_io_extension_point_register
@@ -1124,4 +1244,4 @@
 	fun:calloc
 	...
 	fun:xdg_mime_init
-}
\ No newline at end of file
+}