diff --git a/config.h.meson b/config.h.meson
index fd0bfcaf9..291b668cd 100644
--- a/config.h.meson
+++ b/config.h.meson
@@ -689,9 +689,6 @@
 /* Define to the version of this package. */
 #mesondefine PACKAGE_VERSION
 
-/* define if posix_memalign() can allocate any size */
-#mesondefine POSIX_MEMALIGN_WITH_COMPLIANT_ALLOCS
-
 /* The size of `char', as computed by sizeof. */
 #mesondefine SIZEOF_CHAR
 
diff --git a/config.h.win32.in b/config.h.win32.in
index 14ac11d39..af4157259 100644
--- a/config.h.win32.in
+++ b/config.h.win32.in
@@ -704,9 +704,6 @@
 /* Define to the version of this package. */
 #define PACKAGE_VERSION "@GLIB_MAJOR_VERSION@.@GLIB_MINOR_VERSION@.@GLIB_MICRO_VERSION@"
 
-/* define if posix_memalign() can allocate any size */
-/* #undef POSIX_MEMALIGN_WITH_COMPLIANT_ALLOCS */
-
 /* The size of `char', as computed by sizeof. */
 #define SIZEOF_CHAR 1
 
diff --git a/configure.ac b/configure.ac
index be48c9a19..55471d34d 100644
--- a/configure.ac
+++ b/configure.ac
@@ -1335,48 +1335,6 @@ if test x$glib_cv_langinfo_abaltmon = xyes; then
 fi
 AC_LANG_RESTORE
 
-dnl ****************************************
-dnl *** posix_memalign                   ***
-dnl ****************************************
-AC_MSG_CHECKING(for a compliant posix_memalign() implementation)
-AC_CACHE_VAL(glib_cv_compliant_posix_memalign,[
-    glib_cv_compliant_posix_memalign=0
-    if test "$ac_cv_func_posix_memalign" = "yes" ; then
-	AC_TRY_RUN([
-                #define _XOPEN_SOURCE 600
-                #include <stdlib.h> /* posix_memalign() should be defined here */
-                /* some systems break if #include <malloc.h> used */
-		static void test_memalign (size_t boundary, size_t size) {
-		    void *mem = 0;
-		    if (posix_memalign (&mem, boundary, size) != 0 || !mem)
-			exit (1);
-                    else
-                      free (mem);
-		}
-		int main() {
-		    test_memalign (  128,   128 - 2 * sizeof (void*));
-		    test_memalign (  256,   256 - 2 * sizeof (void*));
-		    test_memalign (  512,   512 - 2 * sizeof (void*));
-		    test_memalign ( 1024,  1024 - 2 * sizeof (void*));
-		    test_memalign ( 2048,  2048 - 2 * sizeof (void*));
-		    test_memalign ( 4096,  4096 - 2 * sizeof (void*));
-		    test_memalign ( 8192,  8192 - 2 * sizeof (void*));
-		    test_memalign (16384, 16384 - 2 * sizeof (void*));
-		    test_memalign (32768, 32768 - 2 * sizeof (void*));
-		    exit (0); /* success */
-		}
-		],
-	    [glib_cv_compliant_posix_memalign=1], [], [:])
-      :
-    fi
-    ])
-AS_IF([test "$glib_cv_compliant_posix_memalign" = "1"], [
-    AC_MSG_RESULT(yes)
-    AC_DEFINE(POSIX_MEMALIGN_WITH_COMPLIANT_ALLOCS, 1, [define if posix_memalign() can allocate any size])
-], [
-    AC_MSG_RESULT(no)
-])
-
 
 dnl ****************************************
 dnl *** strlcpy/strlcat                  ***
diff --git a/glib/gslice.c b/glib/gslice.c
index 48e4c5a33..d1b1fc639 100644
--- a/glib/gslice.c
+++ b/glib/gslice.c
@@ -19,11 +19,7 @@
 #include "config.h"
 #include "glibconfig.h"
 
-#if     defined HAVE_POSIX_MEMALIGN && defined POSIX_MEMALIGN_WITH_COMPLIANT_ALLOCS
-#  define HAVE_COMPLIANT_POSIX_MEMALIGN 1
-#endif
-
-#if defined(HAVE_COMPLIANT_POSIX_MEMALIGN) && !defined(_XOPEN_SOURCE)
+#if defined(HAVE_POSIX_MEMALIGN) && !defined(_XOPEN_SOURCE)
 #define _XOPEN_SOURCE 600       /* posix_memalign() */
 #endif
 #include <stdlib.h>             /* posix_memalign() */
@@ -416,7 +412,7 @@ g_slice_init_nomessage (void)
   mem_assert ((sys_page_size & (sys_page_size - 1)) == 0);
   slice_config_init (&allocator->config);
   allocator->min_page_size = sys_page_size;
-#if HAVE_COMPLIANT_POSIX_MEMALIGN || HAVE_MEMALIGN
+#if HAVE_POSIX_MEMALIGN || HAVE_MEMALIGN
   /* allow allocation of pages up to 8KB (with 8KB alignment).
    * this is useful because many medium to large sized structures
    * fit less than 8 times (see [4]) into 4KB pages.
@@ -1394,13 +1390,12 @@ slab_allocator_free_chunk (gsize    chunk_size,
 
 /* from config.h:
  * define HAVE_POSIX_MEMALIGN           1 // if free(posix_memalign(3)) works, <stdlib.h>
- * define HAVE_COMPLIANT_POSIX_MEMALIGN 1 // if free(posix_memalign(3)) works for sizes != 2^n, <stdlib.h>
  * define HAVE_MEMALIGN                 1 // if free(memalign(3)) works, <malloc.h>
  * define HAVE_VALLOC                   1 // if free(valloc(3)) works, <stdlib.h> or <malloc.h>
  * if none is provided, we implement malloc(3)-based alloc-only page alignment
  */
 
-#if !(HAVE_COMPLIANT_POSIX_MEMALIGN || HAVE_MEMALIGN || HAVE_VALLOC)
+#if !(HAVE_POSIX_MEMALIGN || HAVE_MEMALIGN || HAVE_VALLOC)
 static GTrashStack *compat_valloc_trash = NULL;
 #endif
 
@@ -1410,7 +1405,7 @@ allocator_memalign (gsize alignment,
 {
   gpointer aligned_memory = NULL;
   gint err = ENOMEM;
-#if     HAVE_COMPLIANT_POSIX_MEMALIGN
+#if     HAVE_POSIX_MEMALIGN
   err = posix_memalign (&aligned_memory, alignment, memsize);
 #elif   HAVE_MEMALIGN
   errno = 0;
@@ -1454,7 +1449,7 @@ static void
 allocator_memfree (gsize    memsize,
                    gpointer mem)
 {
-#if     HAVE_COMPLIANT_POSIX_MEMALIGN || HAVE_MEMALIGN || HAVE_VALLOC
+#if     HAVE_POSIX_MEMALIGN || HAVE_MEMALIGN || HAVE_VALLOC
   free (mem);
 #else
   mem_assert (memsize <= sys_page_size);