--- a/Lib/test/test_venv.py
+++ b/Lib/test/test_venv.py
@@ -438,6 +438,7 @@ class EnsurePipTest(BaseTest):
                                     ' module unconditionally')
     # Issue #26610: pip/pep425tags.py requires ctypes
     @unittest.skipUnless(ctypes, 'pip requires ctypes')
+    @unittest.skip("Doesn't work with modified wheels")
     @requires_zlib
     def test_with_pip(self):
         self.do_test_with_pip(False)