diff --git a/QtPy-2.0.1.tar.gz b/QtPy-2.0.1.tar.gz
deleted file mode 100644
index f8885cf..0000000
--- a/QtPy-2.0.1.tar.gz
+++ /dev/null
@@ -1,3 +0,0 @@
-version https://git-lfs.github.com/spec/v1
-oid sha256:adfd073ffbd2de81dc7aaa0b983499ef5c59c96adcfdcc9dea60d42ca885eb8f
-size 43047
diff --git a/QtPy-2.1.0.tar.gz b/QtPy-2.1.0.tar.gz
new file mode 100644
index 0000000..e2355c5
--- /dev/null
+++ b/QtPy-2.1.0.tar.gz
@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:ca8cd4217175186344299ee4c0f7e7adcf362c70852ba35b255a534077025c06
+size 46470
diff --git a/python-QtPy.changes b/python-QtPy.changes
index 9de2e27..6708430 100644
--- a/python-QtPy.changes
+++ b/python-QtPy.changes
@@ -1,3 +1,31 @@
+-------------------------------------------------------------------
+Fri Jun  3 19:09:24 UTC 2022 - Ben Greiner <code@bnavigator.de>
+
+- Update to 2.1.0
+  * PR: Restrict broken Pytest versions to those not affected by
+    the Pytest 7.0.0 import-mode=importlib behavior regression by
+    @CAM-Gerlach in #324
+  * PR: Monkey patch pyside2uic UIParser.readResources for Python
+    3.9 compatibility by @n-elie in #325
+  * PR: Add missing QWebEngineScript support for PyQt5/6 and
+    PySide2/6 by @EasyIsrael in #326
+  * PR: Add missing Qt.MidButton on PyQt6 by @dalthviz in #328
+  * PR: Drop support for Python 3.6 by @dalthviz in #329
+  * PR: Fix typo in constant name by @eyllanesc in #330
+  * PR: Use QFileDialog.Option to be compatiable with Qt6 by
+    @frmdstryr in #331
+  * PR: Skip import of QOpenGLTime* on architectures where not
+    available by @juliangilbey in #333
+  * PR: Remove QHeaderView patch related files by @dalthviz in #334
+  * PR: Fix uic skipped tests and PyQt 6.3.0 segfaulting tests by
+    @dalthviz in #335
+  * PR: Add command line support for Mypy by @CAM-Gerlach in #337
+  * PR: Add workaround for mode argument in
+    QTextCursor.movePosition (Pyside2) by @rear1019 in #341
+  * PR: Fix bug with environ handling by @larsoner in #340
+  * PR: Change bindings try order to be PyQt5, PySide2, PyQt6,
+    PySide6 by @dalthviz in #343
+
 -------------------------------------------------------------------
 Mon Apr 11 08:03:56 UTC 2022 - Ben Greiner <code@bnavigator.de>
 
diff --git a/python-QtPy.spec b/python-QtPy.spec
index 4216e5f..30ab20e 100644
--- a/python-QtPy.spec
+++ b/python-QtPy.spec
@@ -33,30 +33,34 @@ BuildArch:      noarch
 %bcond_with pyside2
 %endif
 # unfortunately we get a segfault in the other backends when pyside6 is installed at the same time (!?)
+# test locally: osc build -M test --with pyside6 --without pyside2 --without pyqt5 --without pyqt6 --define "pythons python3"
 %bcond_with pyside6
 
-%{?!python_module:%define python_module() python3-%{**}}
 %define skip_python2 1
 Name:           python-QtPy%{psuffix}
-Version:        2.0.1
+Version:        2.1.0
 Release:        0
 Summary:        Abstraction layer on top of Qt bindings
 License:        MIT
 Group:          Development/Languages/Python
 URL:            https://github.com/spyder-ide/qtpy
 Source:         https://files.pythonhosted.org/packages/source/Q/QtPy/QtPy-%{version}.tar.gz
+BuildRequires:  %{python_module base >= 3.7}
 BuildRequires:  %{python_module packaging}
 BuildRequires:  %{python_module setuptools}
 BuildRequires:  fdupes
 BuildRequires:  python-rpm-macros
 Requires:       python-packaging
-# Note: Don't add any Requires, Recommends, or Suggests here,
-# because we need to minimize the space occupied on the
-# Tumbleweed DVD. The application importing QtPy will have to
-# know what backend to recommend and what extras to require (e.g.
-# qtwebengine). Note that setup.py does not declare any requirements,
-# in this regard either.
+Requires(post): update-alternatives
+Requires(postun):update-alternatives
+# Note: Don't add any Requires, Recommends, or Suggests for a
+# specific backend here, because we need to minimize the space
+# occupied on the Tumbleweed DVD. The application importing QtPy
+# will have to know what backend to recommend and what extras to
+# require (e.g. qtwebengine). Note that setup.py does not declare
+# any requirements, in this regard either.
 %if %{with test}
+BuildRequires:  %{python_module QtPy = %{version}}
 BuildRequires:  %{python_module pytest >= 6}
 BuildRequires:  %{python_module pytest-qt}
 %if %{with pyqt5}
@@ -93,11 +97,11 @@ BuildRequires:  qt6-sql-sqlite
 QtPy is a small abstraction layer that lets you
 write applications using a single API call to either PyQt or PySide.
 
-It provides support for PyQt5, PyQt4 and PySide using the PyQt5 layout (where
-the QtGui module has been split into QtGui and QtWidgets).
-
-Basically, you can write your code as if you were using PySide2 but import Qt
-modules from qtpy instead of PySide2 (or PyQt5)
+It provides support for PyQt5, PyQt6, PySide6, PySide2 using the Qt5
+layout (where the QtGui module has been split into QtGui and QtWidgets).
+Basically, you can write your code as if you were using PyQt or PySide
+directly, but import Qt modules from qtpy instead of PyQt5, PySide2,
+PyQt6 or PySide6.
 
 %prep
 %setup -q -n QtPy-%{version}
@@ -105,6 +109,7 @@ modules from qtpy instead of PySide2 (or PyQt5)
 sed -i 's/\r$//' LICENSE.txt *.md
 # qtcharts is present in our PyQt
 sed -i '/skipif.*not PYSIDE2/ d' qtpy/tests/test_qtcharts.py
+sed -i '/addopts/ s/--cov=.*//' pytest.ini
 
 %build
 %python_build
@@ -112,6 +117,7 @@ sed -i '/skipif.*not PYSIDE2/ d' qtpy/tests/test_qtcharts.py
 %install
 %if ! %{with test}
 %python_install
+%python_clone -a %{buildroot}%{_bindir}/qtpy
 %python_expand %fdupes %{buildroot}%{$python_sitelib}
 %endif
 
@@ -121,6 +127,8 @@ export QT_HASH_SEED=0
 export QT_QPA_PLATFORM="offscreen"
 mkdir empty
 pushd empty
+# expects an unset FORCE_QT_API
+donttest_qt_api="test_qt_api_environ"
 %ifarch %{arm} aarch64
 # no QtOpenGL for these platforms
 donttest=" or test_qtopengl"
@@ -133,7 +141,7 @@ donttest_pyqt5=" or test_qtsensors"
 donttest_pyqt5="${donttest_pyqt5} or test_qtwebengine or test_qt_api"
 %endif
 export QT_API=pyqt5 FORCE_QT_API=1
-%pytest -rwEfs -v ../qtpy/tests/ -k "not (dummyprefix $donttest $donttest_pyqt5)"
+%pytest -rwEfs -v ../qtpy -k "not ($donttest_qt_api $donttest $donttest_pyqt5)"
 %endif
 %if %{with pyqt6}
 %ifarch %{ix86} %{arm} %{power64} s390x
@@ -142,25 +150,36 @@ export QT_API=pyqt5 FORCE_QT_API=1
 donttest_pyqt6=" or test_qtwebengine"
 %endif
 export QT_API=pyqt6 FORCE_QT_API=1
-%pytest -rwEfs -v ../qtpy/tests/ -k "not (dummyprefix $donttest $donttest_pyqt6)"
+%pytest -rwEfs -v ../qtpy -k "not ($donttest_qt_api $donttest $donttest_pyqt6)"
 %endif
 %if %{with pyside2}
 export QT_API=pyside2 FORCE_QT_API=1
-pytest-%{python3_bin_suffix} -rwEfs -v ../qtpy/tests/ -k "not (dummyprefix $donttest)"
+pytest-%{python3_bin_suffix} -rwEfs -v ../qtpy -k "not ($donttest_qt_api $donttest)"
 %endif
 %if %{with pyside6}
 export QT_API=pyside6 FORCE_QT_API=1
-pytest-%{python3_bin_suffix} -rwEfs -v ../qtpy/tests/ -k "not (dummyprefix $donttest)"
+pytest-%{python3_bin_suffix} -rwEfs -v ../qtpy -k "not ($donttest_qt_api $donttest)"
 %endif
+# Default backend
+unset QT_API
+unset FORCE_QT_API
+%pytest -rwEfs -vvv ../qtpy -k "not (dummyprefix $donttest $donttest_pyqt5)"
 popd
 %endif
 
+%post
+%python_install_alternative qtpy
+
+%postun
+%python_uninstall_alternative qtpy
+
 %if ! %{with test}
 %files %{python_files}
 %doc AUTHORS.md CHANGELOG.md README.md
 %license LICENSE.txt
 %{python_sitelib}/qtpy
 %{python_sitelib}/QtPy-%{version}*-info
+%python_alternative %{_bindir}/qtpy
 %endif
 
 %changelog