diff --git a/astropy-5.0.4.tar.gz b/astropy-5.0.4.tar.gz
deleted file mode 100644
index 2f315d2..0000000
--- a/astropy-5.0.4.tar.gz
+++ /dev/null
@@ -1,3 +0,0 @@
-version https://git-lfs.github.com/spec/v1
-oid sha256:001184f1a9c3f526a363883ce28efb9cbf076df3d151ca3e131509a248f0dfb9
-size 7851964
diff --git a/astropy-5.1.tar.gz b/astropy-5.1.tar.gz
new file mode 100644
index 0000000..0bbb68d
--- /dev/null
+++ b/astropy-5.1.tar.gz
@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:1db1b2c7eddfc773ca66fa33bd07b25d5b9c3b5eee2b934e0ca277fa5b1b7b7e
+size 7924234
diff --git a/python-astropy-rpmlintrc b/python-astropy-rpmlintrc
index 39b9ae4..2daecec 100644
--- a/python-astropy-rpmlintrc
+++ b/python-astropy-rpmlintrc
@@ -1,6 +1,3 @@
 addFilter('devel-file-in-non-devel-package .*/wcs/.*')
 addFilter('hidden-file-or-dir .*/tests/data/.*')
 addFilter('zero-length .*/tests/data/.*')
-# https://bugzilla.opensuse.org/show_bug.cgi?id=1191584
-addFilter('unstripped-binary-or-object .*python.*\.so')
-addFilter('shared-library-without-dependency-information .*python.*\.so')
diff --git a/python-astropy.changes b/python-astropy.changes
index 74ae3be..a6ec9bf 100644
--- a/python-astropy.changes
+++ b/python-astropy.changes
@@ -1,3 +1,23 @@
+-------------------------------------------------------------------
+Thu May 26 15:46:09 UTC 2022 - Ben Greiner <code@bnavigator.de>
+
+- Update to 5.1
+  * Astropy 5.1 is a major release that adds significant new
+    functionality since the 5.0 LTS release.
+  * In particular, this release includes:
+    - Updates to cosmology
+    - doppler_redshift() equivalency
+    - Specifying data types when reading ASCII tables
+    - Structured Columns
+    - New model fitters have been added
+    - Allow time conversions without predictive Earth rotation data
+      (IERS-A)
+    - Uncertainty classes can be transformed into each other
+    - Schechter1D Model
+  * In addition to these major changes, Astropy v5.1 includes a
+    large number of smaller improvements and bug fixes, which are
+    described in the Full Changelog.
+
 -------------------------------------------------------------------
 Sat Apr 23 19:27:14 UTC 2022 - Ben Greiner <code@bnavigator.de>
 
diff --git a/python-astropy.spec b/python-astropy.spec
index 4031926..b8f8e3f 100644
--- a/python-astropy.spec
+++ b/python-astropy.spec
@@ -56,7 +56,7 @@
 %{?!python_module:%define python_module() python3-%{**}}
 %define         skip_python2 1
 Name:           python-astropy%{psuffix}
-Version:        5.0.4
+Version:        5.1
 Release:        0
 Summary:        Community-developed python astronomy tools
 License:        BSD-3-Clause
@@ -99,7 +99,7 @@ Recommends:     python-matplotlib >= 3.1
 Recommends:     python-mpmath
 Recommends:     python-pandas
 Recommends:     python-pyarrow >= 5
-Recommends:     python-scipy >= 1.1
+Recommends:     python-scipy >= 1.3
 Recommends:     python-setuptools
 Recommends:     python-sortedcontainers
 Recommends:     python-typing_extensions >= 3.10.0.1
@@ -117,7 +117,7 @@ BuildRequires:  pkgconfig(wcslib) >= 7
 %if %{with test}
 # SECTION Optional requirements
 BuildRequires:  %{python_module Bottleneck}
-BuildRequires:  %{python_module asdf >= 2.9.2}
+BuildRequires:  %{python_module asdf >= 2.10.0}
 BuildRequires:  %{python_module beautifulsoup4}
 BuildRequires:  %{python_module bleach}
 BuildRequires:  %{python_module h5py}
@@ -137,7 +137,8 @@ BuildRequires:  %{python_module astropy = %{version}}
 BuildRequires:  %{python_module ipython >= 4.2}
 BuildRequires:  %{python_module objgraph}
 BuildRequires:  %{python_module pytest >= 7}
-BuildRequires:  %{python_module pytest-astropy >= 0.9}
+BuildRequires:  %{python_module pytest-astropy >= 0.10}
+BuildRequires:  %{python_module pytest-astropy-header >= 0.2.1}
 BuildRequires:  %{python_module pytest-doctestplus >= 0.12}
 BuildRequires:  %{python_module pytest-mpl}
 BuildRequires:  %{python_module pytest-xdist}
@@ -158,6 +159,8 @@ managing them.
 %autosetup -p1 -n astropy-%{version}
 # avoid rpmlint zero-length error for empty module
 echo '# empty module' > astropy/samp/setup_package.py
+# Reverse gh#astropy/astropy#13205, patch MPL instead
+sed -i '/matplotlib/ s/,!=3.5.2//' setup.cfg
 
 # Make sure bundled libs are not used
 %if %{with system_cfitsio}