diff --git a/biopython-1.80.tar.gz b/biopython-1.80.tar.gz
deleted file mode 100644
index 38368ae..0000000
--- a/biopython-1.80.tar.gz
+++ /dev/null
@@ -1,3 +0,0 @@
-version https://git-lfs.github.com/spec/v1
-oid sha256:52805e9af88767e450e2df8113b5bc59e964e2e8a7bb803a83570bdbb51c0e43
-size 17924553
diff --git a/biopython-1.81.tar.gz b/biopython-1.81.tar.gz
new file mode 100644
index 0000000..0280259
--- /dev/null
+++ b/biopython-1.81.tar.gz
@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:2cf38112b6d8415ad39d6a611988cd11fb5f33eb09346666a87263beba9614e0
+size 19324875
diff --git a/python-biopython.changes b/python-biopython.changes
index 9513a49..32703f3 100644
--- a/python-biopython.changes
+++ b/python-biopython.changes
@@ -1,3 +1,14 @@
+-------------------------------------------------------------------
+Wed Feb 15 14:03:39 UTC 2023 - Dirk Müller <dmueller@suse.com>
+
+- update to 1.81:
+  * The API documentation and the `Biopython Tutorial and
+    Cookbook` have been updated to better annotate use and
+    application of the ``Bio.PDB.internal_coords`` module.
+  * ``Bio.Phylo`` now supports ``Alignment`` and
+    ``MultipleSeqAlignment`` objects as input.
+  * Several improvements and bug fixes to the snapgene parser
+
 -------------------------------------------------------------------
 Wed Jan  4 14:19:49 UTC 2023 - Dirk Müller <dmueller@suse.com>
 
diff --git a/python-biopython.spec b/python-biopython.spec
index 5696976..a1fd36d 100644
--- a/python-biopython.spec
+++ b/python-biopython.spec
@@ -22,7 +22,7 @@
 %define skip_python2 1
 %define skip_python36 1
 Name:           python-biopython
-Version:        1.80
+Version:        1.81
 Release:        0
 Summary:        Python Tools for Computational Molecular Biology
 License:        BSD-3-Clause AND MIT