diff --git a/python-openTSNE-disable-CPU-autodetection.patch b/python-openTSNE-disable-CPU-autodetection.patch
new file mode 100644
index 0000000..8d71b2f
--- /dev/null
+++ b/python-openTSNE-disable-CPU-autodetection.patch
@@ -0,0 +1,26 @@
+Author: Bernhard M. Wiedemann <bwiedemann suse de>
+Date: 2021-04-01
+
+Do not build code using instructions because they are available on a random build worker.
+
+Instead we pin the CPU type to a reasonable compromise
+to allow people to run it on >50% of systems,
+but also to use CPU instructions available since 10+ years
+to speed up processing.
+
+diff --git a/setup.py b/setup.py
+index c00d331..35542b6 100644
+--- a/setup.py
++++ b/setup.py
+@@ -168,9 +168,9 @@ class CythonBuildExt(build_ext):
+         # package is being built locally, this is desired
+         if not ("AZURE_BUILD" in os.environ or "CONDA_BUILD" in os.environ):
+             if platform.machine() == "ppc64le":
+-                extra_compile_args += ["-mcpu=native"]
++                extra_compile_args += ["-mcpu=power8"]
+             if platform.machine() == "x86_64":
+-                extra_compile_args += ["-march=native"]
++                extra_compile_args += ["-march=corei7"]
+ 
+         # We will disable openmp flags if the compiler doesn"t support it. This
+         # is only really an issue with OSX clang
diff --git a/python-openTSNE.changes b/python-openTSNE.changes
index 5eef0d5..ccca8ba 100644
--- a/python-openTSNE.changes
+++ b/python-openTSNE.changes
@@ -1,3 +1,8 @@
+-------------------------------------------------------------------
+Thu Apr  1 07:36:31 UTC 2021 - Bernhard Wiedemann <bwiedemann@suse.com>
+
+- Add python-openTSNE-disable-CPU-autodetection.patch (boo#1100677)
+
 -------------------------------------------------------------------
 Fri Jan 29 19:18:18 UTC 2021 - Ben Greiner <code@bnavigator.de>
 
diff --git a/python-openTSNE.spec b/python-openTSNE.spec
index 4d5fe8d..fdc931f 100644
--- a/python-openTSNE.spec
+++ b/python-openTSNE.spec
@@ -28,6 +28,7 @@ License:        BSD-3-Clause
 URL:            https://github.com/pavlin-policar/openTSNE
 # tests are not packaged in the PyPI sdist, use GitHub instead
 Source:         %{url}/archive/v%{version}.tar.gz#/openTSNE-%{version}-gh.tar.gz
+Patch0:         python-openTSNE-disable-CPU-autodetection.patch
 BuildRequires:  python-rpm-macros
 BuildRequires:  %{python_module setuptools}
 BuildRequires:  %{python_module devel}
@@ -52,7 +53,7 @@ Obsoletes:      python-fastTSNE < %{version}
 Extensible, parallel implementations of t-SNE
 
 %prep
-%setup -q -n openTSNE-%{version}
+%autosetup -p1 -n openTSNE-%{version}
 
 %build
 export CFLAGS="%{optflags}"