Index: VTK/Wrapping/Python/CMakeLists.txt
===================================================================
--- VTK.orig/Wrapping/Python/CMakeLists.txt
+++ VTK/Wrapping/Python/CMakeLists.txt
@@ -540,7 +540,7 @@ IF(PYTHON_EXECUTABLE)
 
     # Create default python setup arguments if they are not set.
     IF(NOT DEFINED VTK_PYTHON_SETUP_ARGS)
-      SET(VTK_PYTHON_SETUP_ARGS "--prefix=\"${DOLLAR}{CMAKE_INSTALL_PREFIX}\""
+      SET(VTK_PYTHON_SETUP_ARGS "--prefix=\"${DOLLAR}{CMAKE_INSTALL_PREFIX}\" --root=\"${DOLLAR}ENV{DESTDIR}\""
         CACHE STRING "Arguments passed to \"python setup.py install ...\" during installation.")
       MARK_AS_ADVANCED(VTK_PYTHON_SETUP_ARGS)
     ENDIF(NOT DEFINED VTK_PYTHON_SETUP_ARGS)