diff -ur VTK//Wrapping/Python/CMakeLists.txt VTK.new//Wrapping/Python/CMakeLists.txt
--- VTK//Wrapping/Python/CMakeLists.txt	2010-09-28 02:10:11.000000000 +0530
+++ VTK.new//Wrapping/Python/CMakeLists.txt	2011-03-23 23:01:48.995000067 +0530
@@ -417,7 +417,7 @@
  
     # Create default python setup arguments if they are not set.
     IF(NOT DEFINED VTK_PYTHON_SETUP_ARGS)
-      SET(VTK_PYTHON_SETUP_ARGS "--prefix=\"${DOLLAR}{CMAKE_INSTALL_PREFIX}\""
+      SET(VTK_PYTHON_SETUP_ARGS "--prefix=\"${DOLLAR}{CMAKE_INSTALL_PREFIX}\" --root=\"${DOLLAR}ENV{DESTDIR}\""
         CACHE STRING "Arguments passed to \"python setup.py install ...\" during installation.")
       MARK_AS_ADVANCED(VTK_PYTHON_SETUP_ARGS)
     ENDIF(NOT DEFINED VTK_PYTHON_SETUP_ARGS)