zabbix-phpfrontend: To enable zabbix frontend in apache type in console: # a2enflag ZABBIX or if you want to remove it from apache configuration type in console: # a2enflag -d ZABBIX # service apache2 restart or reload if apache restart is too disrupting Please, make sure SSL is enabled and up in Apache2 config. You can get inspired by https://www.zabbix.com/documentation/4.0/manual/installation/requirements/best_practices. If you have Apache 2.4.30 or newer, it is even more simple: https://httpd.apache.org/docs/trunk/mod/mod_md.html.