diff --git a/python310.changes b/python310.changes
index 3a37b16..aa566b0 100644
--- a/python310.changes
+++ b/python310.changes
@@ -1,3 +1,8 @@
+-------------------------------------------------------------------
+Mon Mar 10 15:44:31 UTC 2025 - Bernhard Wiedemann <bwiedemann@suse.com>
+
+- Skip PGO with %want_reproducible_builds (bsc#1239210)
+
 -------------------------------------------------------------------
 Tue Feb  4 14:43:13 UTC 2025 - Matej Cepl <mcepl@cepl.eu>
 
diff --git a/python310.spec b/python310.spec
index 25b79e2..a0c2713 100644
--- a/python310.spec
+++ b/python310.spec
@@ -36,7 +36,7 @@
 %bcond_without general
 %endif
 
-%if 0%{?do_profiling}
+%if 0%{?do_profiling} && !0%{?want_reproducible_builds}
 %bcond_without profileopt
 %else
 %bcond_with profileopt