diff --git a/no-pygtkcompat.patch b/no-pygtkcompat.patch
new file mode 100644
index 0000000..59eb1df
--- /dev/null
+++ b/no-pygtkcompat.patch
@@ -0,0 +1,32 @@
+diff -ur Twisted-21.7.0.orig/src/twisted/internet/gireactor.py Twisted-21.7.0/src/twisted/internet/gireactor.py
+--- Twisted-21.7.0.orig/src/twisted/internet/gireactor.py
++++ Twisted-21.7.0/src/twisted/internet/gireactor.py
+@@ -24,16 +24,21 @@
+ from twisted.internet.error import ReactorAlreadyRunning
+ from twisted.internet import _glibbase
+ from twisted.python import runtime
+-import gi.pygtkcompat  # type: ignore[import]
+ from gi.repository import GLib  # type: ignore[import]
+ 
+-# We require a sufficiently new version of pygobject, so always exists:
+-_pygtkcompatPresent = True
++try:
++    import gi.pygtkcompat # type: ignore[import]
++except ImportError:
++    pass # This is probably Python 3, with pygtkcompat removed
++else:
++    # We require a sufficiently new version of pygobject, so always exists:
++    _pygtkcompatPresent = True
++
++    # Newer version of gi, so we can try to initialize compatibility layer; if
++    # real pygtk was already imported we'll get ImportError at this point
++    # rather than segfault, so unconditional import is fine.    
++    gi.pygtkcompat.enable()
+ 
+-# Newer version of gi, so we can try to initialize compatibility layer; if
+-# real pygtk was already imported we'll get ImportError at this point
+-# rather than segfault, so unconditional import is fine.
+-gi.pygtkcompat.enable()
+ # At this point importing gobject will get you gi version, and importing
+ # e.g. gtk will either fail in non-segfaulty way or use gi version if user
+ # does gi.pygtkcompat.enable_gtk(). So, no need to prevent imports of
diff --git a/python-Twisted.changes b/python-Twisted.changes
index 0b3f04e..0e24d38 100644
--- a/python-Twisted.changes
+++ b/python-Twisted.changes
@@ -3,6 +3,11 @@ Mon Aug  2 06:41:10 UTC 2021 - Markéta Machová <mmachova@suse.com>
 
 - typing_extensions is now required
 
+-------------------------------------------------------------------
+Sat Jul 31 08:25:30 UTC 2021 - Michael Gumsley <gumsley_6@hotmail.com>
+
+- Restore no-pygtkcompat.patch due to boo#1110669
+
 -------------------------------------------------------------------
 Sat Jul 31 04:27:55 UTC 2021 - Matej Cepl <mcepl@suse.com>
 
diff --git a/python-Twisted.spec b/python-Twisted.spec
index b4a0d9f..a51cffb 100644
--- a/python-Twisted.spec
+++ b/python-Twisted.spec
@@ -36,6 +36,8 @@ Patch2:         no-test_successResultOfWithFailureHasTraceback.patch
 Patch3:         1521_delegate_parseqs_stdlib_bpo42967.patch
 # We don't want to package yet another module, and it is easily skippable
 Patch4:         no-cython_test_exception_raiser.patch
+# boo#1110669 Our variant of PyGObject has pygtkcompat stripped which Twisted does not handle
+Patch5:         no-pygtkcompat.patch
 BuildRequires:  %{python_module Automat >= 0.8.0}
 BuildRequires:  %{python_module PyHamcrest >= 1.9.0}
 BuildRequires:  %{python_module appdirs >= 1.4.0}