diff --git a/python-enaml.changes b/python-enaml.changes
index 183b53e..a9d32a8 100644
--- a/python-enaml.changes
+++ b/python-enaml.changes
@@ -1,3 +1,9 @@
+-------------------------------------------------------------------
+Tue Jun  3 15:05:42 UTC 2025 - Christophe Marin <christophe@krop.fr>
+
+- Drop runtime dependency on pyside2 for Leap 16 and factory
+  (boo#1243916)
+
 -------------------------------------------------------------------
 Wed Nov  6 15:37:22 UTC 2024 - John Paul Adrian Glaubitz <adrian.glaubitz@suse.com>
 
diff --git a/python-enaml.spec b/python-enaml.spec
index 13f77bb..7020938 100644
--- a/python-enaml.spec
+++ b/python-enaml.spec
@@ -43,7 +43,11 @@ Requires:       python-ply
 Requires:       python-QtPy >= 2.1.0
 %if "%{python_flavor}" == "python3" || "%{python_provides}" == "python3"
 # pyside is python3 only, PyQt5 (-qt5) and PyQt6 are multiflavored
+%if 0%{?suse_version} > 1500
+Requires:       (python-qt5 or python-PyQt6 >= 6.3.1 or python3-pyside6 >= 6.2.3)
+%else
 Requires:       (python-qt5 or python-PyQt6 >= 6.3.1 or python3-pyside2 or python3-pyside6 >= 6.2.3)
+%endif
 %else
 Requires:       (python-qt5 or python-PyQt6 >= 6.3.1)
 %endif