diff --git a/_constraints b/_constraints
index 13513d1..e904401 100644
--- a/_constraints
+++ b/_constraints
@@ -2,10 +2,10 @@
 <constraints>
   <hardware>
     <disk>
-      <size unit="G">24</size>
+      <size unit="G">28</size>
     </disk>
     <physicalmemory>
-      <size unit="G">6</size>
+      <size unit="G">12</size>
     </physicalmemory>
   </hardware>
   <overwrite>
@@ -14,7 +14,7 @@
     </conditions>
     <hardware>
       <memoryperjob>
-        <size unit="M">2000</size>
+        <size unit="M">5000</size>
       </memoryperjob>
     </hardware>
   </overwrite>
diff --git a/add-missing-includes.patch b/add-missing-includes.patch
deleted file mode 100644
index 241dfda..0000000
--- a/add-missing-includes.patch
+++ /dev/null
@@ -1,12 +0,0 @@
-Index: ITK-5.3.0/Modules/Filtering/MathematicalMorphology/include/itkMathematicalMorphologyEnums.h
-===================================================================
---- ITK-5.3.0.orig/Modules/Filtering/MathematicalMorphology/include/itkMathematicalMorphologyEnums.h
-+++ ITK-5.3.0/Modules/Filtering/MathematicalMorphology/include/itkMathematicalMorphologyEnums.h
-@@ -20,6 +20,7 @@
- 
- #include <iostream>
- #include "ITKMathematicalMorphologyExport.h"
-+#include <cstdint>
- 
- 
- namespace itk
diff --git a/insighttoolkit-5.3.0.tar.gz b/insighttoolkit-5.3.0.tar.gz
deleted file mode 100644
index c5e18b3..0000000
--- a/insighttoolkit-5.3.0.tar.gz
+++ /dev/null
@@ -1,3 +0,0 @@
-version https://git-lfs.github.com/spec/v1
-oid sha256:64e7e8094a5023c8f68ee042459d6319581fadb35e2fe90a4ae230ce36369db1
-size 21844157
diff --git a/insighttoolkit-5.4.0.tar.gz b/insighttoolkit-5.4.0.tar.gz
new file mode 100644
index 0000000..9df5b95
--- /dev/null
+++ b/insighttoolkit-5.4.0.tar.gz
@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:d71a36fc0aee2c9257fe128f7657feb1e671461bd48561b620619f290c71795e
+size 22509357
diff --git a/insighttoolkit.changes b/insighttoolkit.changes
index 628ab29..4a11752 100644
--- a/insighttoolkit.changes
+++ b/insighttoolkit.changes
@@ -1,3 +1,22 @@
+-------------------------------------------------------------------
+Mon Jul  8 06:30:25 UTC 2024 - Atri Bhattacharya <badshah400@gmail.com>
+
+- Update to version 5.4.0:
+  * No release notes.
+- Drop patches incorporated upstream:
+  * insighttoolkit-swig4_1-compat.patch
+  * add-missing-includes.patch
+- Disable python bindings for openSUSE < 1650 as python >= 3.8 is
+  required and also for openSUSE >= 1650 as an unreleased version
+  of swig is required.
+
+-------------------------------------------------------------------
+Fri Jan 19 12:53:49 UTC 2024 - Atri Bhattacharya <badshah400@gmail.com>
+
+- Add insighttoolkit-swig4_1-compat.patch -- Add swig 4.1+
+  compatibility by defining SWIGPY_SLICEOBJECT; patch picked from
+  upstream commit [gh#InsightSoftwareConsortium/ITK#3782].
+
 -------------------------------------------------------------------
 Mon Nov  6 16:15:38 UTC 2023 - Dominique Leuenberger <dimstar@opensuse.org>
 
diff --git a/insighttoolkit.spec b/insighttoolkit.spec
index e8a62e2..35eff2b 100644
--- a/insighttoolkit.spec
+++ b/insighttoolkit.spec
@@ -1,7 +1,7 @@
 #
 # spec file for package insighttoolkit
 #
-# Copyright (c) 2023 SUSE LLC
+# Copyright (c) 2024 SUSE LLC
 # Copyright (c) 2016 Angelos Tzotsos <tzotsos@opensuse.org>.
 #
 # All modifications and additions to the file contributed by third parties
@@ -19,7 +19,7 @@
 
 %global __builder ninja
 %define tarname ITK
-%define libname lib%{name}5_3-1
+%define libname lib%{name}5_4-1
 
 # Do not use system eigen on aarch64 until fixed upstream:
 # https://github.com/InsightSoftwareConsortium/ITK/issues/2903
@@ -29,23 +29,21 @@
 %bcond_without system_eigen
 %endif
 
-# Python bindings must be turned off until https://github.com/InsightSoftwareConsortium/ITK/issues/3782 is resolved
-%if 0%{?suse_version} >= 1550
+# Python >= 3.8 is required
+%if 0%{?suse_version} > 1650
 %bcond_with python
 %else
-%bcond_without python
+# Unreleased master branch of swig required <https://github.com/InsightSoftwareConsortium/ITK/issues/4746>
+%bcond_with python
 %endif
 
 Name:           insighttoolkit
-Version:        5.3.0
+Version:        5.4.0
 Release:        0
 Summary:        Toolkit for scientific image processing, segmentation, and registration
 License:        Apache-2.0
 URL:            https://www.itk.org
-Source:         https://github.com/InsightSoftwareConsortium/ITK/archive/v%{version}.tar.gz#/%{name}-%{version}.tar.gz
-# PATCH-FIX-UPSTREAM add-missing-includes.patch -- Add missing #include <cstdint>
-Patch0:         add-missing-includes.patch
-
+Source0:        https://github.com/InsightSoftwareConsortium/ITK/archive/v%{version}.tar.gz#/%{name}-%{version}.tar.gz
 BuildRequires:  CastXML-devel
 BuildRequires:  bison
 BuildRequires:  cmake
@@ -71,8 +69,8 @@ BuildRequires:  pkgconfig(libtiff-4)
 BuildRequires:  pkgconfig(libxml-2.0)
 BuildRequires:  pkgconfig(zlib)
 %if %{with python}
-BuildRequires:  python3-devel
-BuildRequires:  swig >= 4.0
+BuildRequires:  python3-devel >= 3.8
+BuildRequires:  swig >= 4.3
 %endif
 %if %{with system_eigen}
 BuildRequires:  pkgconfig(eigen3)
@@ -152,7 +150,6 @@ This package provides the modules for ITK's python bindings.
   -DITK_USE_SYSTEM_SWIG:BOOL=ON \
   -DITK_USE_SYSTEM_VXL:BOOL=OFF \
   -DVXL_BUILD_CORE_NUMERICS:BOOL=OFF \
-  -DVCL_INCLUDE_CXX_0X:BOOL=ON \
   -DITK_FORBID_DOWNLOADS=ON \
   -DITK_WRAP_PYTHON:BOOL=%{?with_python:ON}%{!?with_python:OFF}