diff --git a/synapse/python_dependencies.py b/synapse/python_dependencies.py
index 14ddaed02..eb2137c93 100644
--- a/synapse/python_dependencies.py
+++ b/synapse/python_dependencies.py
@@ -84,7 +84,7 @@ REQUIREMENTS = [
     "typing-extensions>=3.7.4",
     # We enforce that we have a `cryptography` version that bundles an `openssl`
     # with the latest security patches.
-    "cryptography>=3.4.7;python_version>='3.6'",
+    # "cryptography>=3.4.7;python_version>='3.6'",
 ]
 
 CONDITIONAL_REQUIREMENTS = {